Daily Archives: February 4, 2012

Baseline Reform Act passes the US House of Representatives

Baseline budgeting is one of the biggest government scams in history (in my humble opinion)…..passage of this bill is a start in the right direction….

On Friday, February 3, the House passed H.R. 3578, to amend the Balanced Budget and Emergency Deficit Control Act of 1985 to reform the budget baseline, by a yea-and-nay vote of 235 yeas to 177 nays, Roll No. 32. 

Click here for the committee report (House Report 112-378) 

Click here for the full text of the bill.

In effect, the bill changes the current federal baseline budgeting process. From the Committee Report, Section 2:

This section amends section 257 of the Balanced Budget and Emergency Deficit Control Act of 1985 (P.L. 109-59) to remove the increases in the discretionary baseline attributable to inflation, expiring housing contracts, social insurance administrative expenses, and pay annualization. The discretionary spending in the baseline to be calculated uses the following assumptions:

(1) For any estimated appropriations, the budgetary resources other than unobligated balances are to be at the level provided for the budget year in full-year appropriation acts. If a full-year appropriation has not been enacted, budgetary resources, other than unobligated balances, are to be at the level available in the current year.

(2) For any continuing appropriation in effect for less than an entire year, the current-year amount is assumed to equal the amount that would be available if that continuing appropriation lasted the entire fiscal year. If law permits the transfer of budget authority among budget accounts in a current year, the current level is to reflect transfers assumed in the President’s original budget.

UAH Satellite-Based Global Lower Atmospheric Temperature

Source: Dr. Roy Spencer (drroyspencer.com)

Sharma et al 2008: Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion

Sharma, R., M. Tsuchiya, and J.D. Bartlett. Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion. Environ Health Perspect. 2008 Sep;116(9):1142-6.

BACKGROUND: Exposure to excessive amounts of fluoride (F(-)) causes dental fluorosis in susceptible individuals; however, the mechanism of F(-)-induced toxicity is unclear. Previously, we have shown that high-dose F(-) activates the unfolded protein response (UPR) in ameloblasts that are responsible for dental enamel formation. The UPR is a signaling pathway responsible for either alleviating endoplasmic reticulum (ER) stress or for inducing apoptosis of the stressed cells.

OBJECTIVES: In this study we determined if low-dose F(-) causes ER stress and activates the UPR, and we also determined whether F(-) interferes with the secretion of proteins from the ER.

METHODS: We stably transfected the ameloblast-derived LS8 cell line with secreted alkaline phosphatase (SEAP) and determined activity and localization of SEAP and F(-)-mediated induction of UPR proteins. Also, incisors from mice given drinking water containing various concentrations of F(-) were examined for eucaryotic initiation factor-2, subunit alpha (eIF2alpha) phosphorylation.

RESULTS: We found that F(-) decreases the extracellular secretion of SEAP in a linear, dose-dependent manner. We also found a corresponding increase in the intracellular accumulation of SEAP after exposure to F(-). These changes are associated with the induction of UPR proteins such as the molecular chaperone BiP and phosphorylation of the UPR sensor PKR-like ER kinase, and its substrate, eIF2alpha. Importantly, F(-)-induced phosphorylation of eIF2alphawas confirmed in vivo.

CONCLUSIONS: These data suggest that F(-) initiates an ER stress response in ameloblasts that interferes with protein synthesis and secretion. Consequently, ameloblast function during enamel development may be impaired, and this may culminate in dental fluorosis.

Click here for the full paper (free).