Blaylock, R.L. Excitotoxicity: A Possible Central Mechanism in Fluoride Neurotoxicity. Fluoride. 2004; 37(4):301-314.
Recent evidence indicates that fluoride fluoride produces neuronal destruction and synaptic injury by a mechanism that involves free radical production and lipid peroxidation. For a number of pathological disorders of the central nervous system (CNS), excitotoxicity plays a critical role. Various studies have shown that many of the neurotoxic metals, such as mercury, lead, aluminum, and iron also injure neural elements in the CNS by an excitotoxic mechanism. Free radical generation and lipid peroxidation, also magnify excitotoxic sensitivity of neurons and their elements. This paper reviews briefly some of the studies that point to a common mechanism for CNS neurotoxic effects of fluoride and calls for research directed towards elucidation of this mechanism.
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