Daily Archives: February 14, 2013

…”exposures to low concentrations of NaF may induce renal damage”…

Santoyo-Sanchez MP, Del Carmen Silva-Lucero M, Arreola-Mendoza L, Barbier OC. Effects of Acute Sodium Fluoride Exposure on Kidney Function, Water Homeostasis, and Renal Handling of Calcium and Inorganic Phosphate. Biol Trace Elem Res. 2013 Feb 12.

Fluoride compounds are abundant and widely distributed in the environment at a variety of concentrations. Further, fluoride induces toxic effects in target organs such as the liver and kidney. In this study, we performed an early analysis of renal function using a clearance technique in Wistar rats acutely exposed to fluoride at a plasma concentration of 0.625 μg/ml. Our results revealed that fluoride, at a concentration close to the concentration present in the serum after environmental exposure, induced a significant tubular dysfunction, resulting in diluted urine, impaired protein reabsorption, and increased calcium and phosphate urinary excretion. Our work demonstrates that even acute exposures to low concentrations of NaF may induce renal damage and confirms that, after exposure, the kidney participates directly in the calcium and phosphate deficiencies observed in fluoride-exposed populations.

Click here for full paper (Open Access).


Risk of congenital anomalies from trihalomethane exposure during pregnancy

Grazuleviciene R, Kapustinskiene V, Vencloviene J, Buinauskiene J, Nieuwenhuijsen MJ. Risk of congenital anomalies in relation to the uptake of trihalomethane from drinking water during pregnancy. Occup Environ Med. 2013 Feb 12.

OBJECTIVES: Congenital anomalies have been inconsistently associated with maternal crude estimated exposure to drinking water trihalomethane (THM). We investigated the relationship between individual THM uptake during the first trimester of pregnancy and congenital anomalies.

METHODS: We estimated maternal THM uptake for 3074 live births using residential tap water concentrations, drinking water ingestion, showering and bathing, and uptake factors of THM in the blood. Multiple logistic regression was used to investigate the association of THM exposure with congenital anomalies.

RESULTS: We observed no statistically significant relationships between congenital anomalies and the total THM internal dose. We found little indication of a dose-response relationship for brominated THM and congenital heart anomalies. The relationship was statistically significant for bromodichloromethane (BDCM) (OR=2.16, 95% CI 1.05 to 4.46, highest vs lowest tertile) during the first month of pregnancy. During the first trimester of pregnancy, the probability of developing heart anomalies increased for every 0.1 μg/d increase in the BDCM and for every 0.01 μg/d increase in the internal dibromochloromethane (DBCM) dose (OR 1.70, 95% CI 1.09 to 2.66, and OR 1.25, 95% CI 1.01 to 1.54, respectively). A dose-response relationship was evident for musculoskeletal anomalies and DBCM exposure during the first and second months of pregnancy, while BDCM exposure tended to increase the risk of urogenital anomalies.

CONCLUSIONS: This study shows some evidence for an association between the internal dose of THM and the risk of congenital anomalies. In particular, increased prenatal exposure to brominated THM might increase the risk of congenital heart and musculoskeletal anomalies.

Click here for full paper (Open Access).

Boxer-Sanders Carbon Tax bill misguided at best, sacrifices people today

The bill introduced today by Senator’s Boxer and Sanders is a misguided effort. The underlying premise is that carbon dioxide in the atmosphere must be controlled to avoid runaway global warming. A tax would be imposed on large carbon emitters but not smaller emission sources. Local residents would be refunded 3/5 of the taxes (click here). An interesting idea, but would it encourage more mining, not less….

A major flaw in this tax proposal, as well as cap and trade, is the fact that taxes taken out of the economy lowers income resulting in poorer and riskier living conditions. In other words, lives are sacrificed today. There is a real health risk caused by poorer living conditions today which is being ignored.