Lung and Bladder Cancer in Northern Chile: Arsenic, Tobacco Smoke, Occupation

The primary difficulty with such studies as these is that US exposure levels are nowhere near these arsenic concentrations in Chile. Hence, this study is not relevant to the United States. The multiplicative effect of smoking on the effect of exposure to certain contaminants has been previously demonstrated.

Ferreccio C, Yuan Y, Calle J, Benítez H, Parra RL, Acevedo J, Smith AH, Liaw J, Steinmaus C. Arsenic, Tobacco Smoke, and Occupation: Associations of Multiple Agents with Lung and Bladder Cancer. Epidemiology. 2013 Sep 12.

BACKGROUND: Millions of people worldwide are exposed to arsenic in drinking water, and many are likely coexposed to other agents that could substantially increase their risks of arsenic-related cancer.

METHODS: We performed a case-control study of multiple chemical exposures in 538 lung and bladder cancer cases and 640 controls in northern Chile, an area with formerly high drinking water arsenic concentrations. Detailed information was collected on lifetime arsenic exposure, smoking, secondhand smoke, and other known or suspected carcinogens, including asbestos, silica, and wood dust.

RESULTS: Very high lung and bladder cancer odds ratios (ORs), and evidence of greater than additive effects, were seen in people exposed to arsenic concentrations >335 µg/L and who were tobacco smokers (OR = 16, 95% confidence interval = 6.5-40 for lung cancer; and OR = 23 [8.2-66] for bladder cancer; Rothman Synergy Indices = 4.0 [1.7-9.4] and 2.0 [0.92-4.5], respectively). Evidence of greater than additive effects were also seen in people coexposed to arsenic and secondhand tobacco smoke and several other known or suspected carcinogens, including asbestos, silica, and wood dust.

CONCLUSIONS: These findings suggest that people coexposed to arsenic and other known or suspected carcinogens have very high risks of lung or bladder cancer.

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