Daily Archives: December 23, 2013

Harmful effects of sodium fluoride on reproduction

Zhou Y, Qiu Y, He J, Chen X, Ding Y, Wang Y, Liu X. The toxicity mechanism of sodium fluoride on fertility in female rats. Food Chem Toxicol. 2013 Dec;62:566-72. doi: 10.1016/j.fct.2013.09.023.

Recognition of the harmful effects of sodium fluoride (NaF) on human reproduction is increasing, especially as it relates to female reproduction. However, the mechanism by which NaF interferes with female reproduction is unclear. The aims of the present study were to investigate the effects offluoride exposure on female fertility and to elucidate the mechanisms underlying these effects. Female Sprague-Dawley rats were divided into three groups: one control group and two NaF-treated groups (100 and 200mg/L in the drinking water for 12weeks). Several parameters were evaluated, including: (i) fluoride concentrations; (ii) estrogen (E2) and progesterone (P) concentrations; (iii) estrogen receptor alpha protein (ERα); (iv) progesterone receptor (PgR) protein; (v) follicle-stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHR) protein. The results indicated that administration of NaF lead to significant decreases in E2 and P levels in the serum and in the expression of FSHR protein. In addition,fluoride exposure significantly increased Erα and PgR protein expression levels and LHR protein expression. These results suggest that the reproductive hormone reduction and the abnormalities of related receptor proteins expression are important factors underlying the decreased fertility observed in female rats that have been exposed to NaF.

Click here for full paper (fee).

Surface water quality models

Wang Q, Li S, Jia P, Qi C, Ding F.  A review of surface water quality models. ScientificWorldJournal. 2013 Jun 17;2013:231768. doi: 10.1155/2013/231768.


Surface water quality models can be useful tools to simulate and predict the levels, distributions, and risks of chemical pollutants in a given waterbody. The modeling results from these models under different pollution scenarios are very important components of environmental impact assessment and can provide a basis and technique support for environmental management agencies to make right decisions. Whether the model results are rightor not can impact the reasonability and scientificity of the authorized construct projects and the availability of pollution control measures. We reviewed the development of surface water quality models at three stages and analyzed the suitability, precisions, and methods among different models. Standardization of water quality models can help environmental management agencies guarantee the consistency in application of water quality models for regulatory purposes. We concluded the status of standardization of these models in developed countries and put forward available measures for the standardization of these surface water quality models, especially in developing countries.

Click here for full paper (Open Source).