Daily Archives: March 25, 2014

Sotomayor, Kagan say Hobby Lobby should cancel health insurance

“During oral arguments in the U.S. Supreme Court on Tuesday which focused on whether the contraceptive mandate in the Affordable Care Act violates the free exercise of religion, Justices Sonia Sotomayor and Elena Kagan suggested employers who have moral objections to birth control should not provide health care coverage for their employees.” click here

This is judicial tyranny at its worst.



Dental fluorosis in paediatric patients

GS Atia, J May. Dental fluorosis in the paediatric patient. Dent Update. 2013 Dec;40(10):836-9.

Exposure to excessive fluoride intake during the early childhood years can disrupt the normal development of enamel, resulting in dental fluorosis. This varies in severity, ranging from white opacities in mild cases to more severe black and brown discoloration or enamel pitting. This article aims to give the reader a better understanding of the aetiology, diagnosis and subsequent treatment of dental fluorosis in the paediatric patient.

CLINICAL RELEVANCE: Fluorosis can have a marked effect on dental aesthetics. The prevalence of fluorosis in the United Kingdom may increase following the publication of Delivering Better Oral Health, published by the Department of Health in 2007, which suggested changes to fluoride levels in children’s toothpastes. This article highlights the importance of accurate diagnosis of fluorosis and also explains the treatment options available to paediatric patients.

WHO World Health Report 2000 was a fraud

 “In fact, World Health Report 2000 was an intellectual fraud of historic consequence—a profoundly deceptive document that is only marginally a measure of health-care performance at all. The report’s true achievement was to rank countries according to their alignment with a specific political and economic ideal—socialized medicine—and then claim it was an objective measure of “quality.” “

Click here for full article.

Blood trihalomethane levels decreased from 1999 to 2006

AM Riederer, R Dhingra, K Blount, K Steenland. Predictors of Blood Trihalomethane Concentrations in NHANES 1999-2006. Environ Health Perspect. 2014 Mar 19.

BACKGROUND: Trihalomethanes (THMs) are water disinfection by-products that have been associated with bladder cancer and adverse birth outcomes. Four (bromoform, chloroform, bromodichloromethane, dibromochloromethane) were measured in blood and tap water of U.S. adults in NHANES 1999-2006. THMs are metabolized to potentially toxic/mutagenic intermediates by cytochrome p450 (CYP) 2D6 and CYP2E1 enzymes.

OBJECTIVES: We conducted exploratory analyses of blood THMs including factors affecting CYP2D6 and CYP2E1 activity.

METHODS: We used weighted multivariable regression to evaluate associations between blood THMs and water concentrations, survey year, and other factors potentially affecting THM exposure or metabolism (e.g., prescription medications, cruciferous vegetables, diabetes, fasting, pregnancy, swimming).

RESULTS: From 1999-2006, geometric mean blood and water THM levels dropped in parallel-32%-76% in blood and 38%-52% in water-likely resulting, in part, from the lowering of the total THM drinking water standard in 2002-2004. The strongest predictors of blood THM levels were survey year and water concentration (N=4,232 total THM; N=4,582 chloroform; N=4,080 bromoform; N=4,374 bromodichloromethane; N=4,464 dibromochloromethane). Statistically significant inverse associations were detected with diabetes and eating cruciferous vegetables in all but the bromoform model. Medications did not consistently predict blood levels. Afternoon/evening blood samples had lower THM concentrations than morning samples. In a sub-sample (n=230), air chloroform better predicted blood chloroform than water chloroform, suggesting showering/bathing was a more important source than drinking.

CONCLUSIONS: We identified several factors associated with blood THMs which may be factors affecting their metabolism; potential health implications require further study.