Daily Archives: April 19, 2015

“Sustainability” is Higher Education’s New Fundamentalism, Restricts Debate

““Sustainability” is a key idea on college campuses in the United States and the rest of the Western world. To many, sustainability is just a new name for environmentalism. But the word has come to mean something much larger: an ideology that demands new limits on economic, political, and intellectual freedom as the price that must be paid to ensure the welfare of future generations.” full report is here.

Sodium Fluoride Adversely Effects Male Fertility

Kim J, Kwon WS, Rahman MS, Lee JS, Yoon SJ, Park YJ, You YA, Pang MG. Effect of sodium fluoride on male fertility. Andrology. 2015 Apr 8. doi: 10.1111/andr.12006.

Sodium fluoride (NaF), an environmental pollutant, has been tested for its impact on fertility in several species of laboratory animals. A literature demonstrated that NaF adversely affects sperm motility, morphology, capacitation, and the acrosome reaction. However, the molecular mechanisms underlying these alterations have not yet been elucidated. Therefore, present study was designed to evaluate the regulatory pathways involved in the effect of NaF on sperm function and fertilization. In this in vitro study, mouse spermatozoa were incubated with a range of concentrations (2.5, 5, and 10 mm) of NaF for 90 min in media that support in vitro fertilization. Our results showed that NaF was associated with reduced intracellular ATP generation, motility, and motion kinematics. Likewise, short-term exposure of spermatozoa to NaF significantly reduced the intracellular calcium concentration, protein kinase-A activity, and tyrosine phosphorylation of sperm proteins, which were associated with a significant decrease in the rate of capacitation and the acrosome reaction. Finally, NaF significantly reduced the fertilization and blastocyst formation during early embryonic development. On the basis of these results, we propose that NaF reduces sperm motility, capacitation, and the acrosome reaction leading to poor fertilization and suppressed embryonic development.

Click here for paper (fee).