NikNadia N, Sam IC, Khaidir N, Ngui R, Lim YA, Goh XT, Choy SH, Chan YF. Risk Factors for Enterovirus A71 Seropositivity in Rural Indigenous Populations in West Malaysia. PLoS One. 2016 Feb 11;11(2):e0148767. doi: 10.1371/journal.pone.0148767.
Enterovirus A71 (EV-A71), which is transmitted by the fecal-oral route, causes hand, foot and mouth disease and, rarely, severe neurological complications. In Malaysia, the indigenous rural community (Orang Asli) has a high prevalence of parasitic diseases due to poor sanitation, water supply and hygiene practices. This cross-sectional study compared the seroepidemiology of EV-A71 among rural Orang Asli and urban Kuala Lumpur populations in West Malaysia, and determined the risk factors associated with EV-A71 seropositivity in rural Orang Asli. Seropositive rates were determined by neutralization assay. EV-A71 seropositivity was strongly associated with increasing age in both populations. Rural Orang Asli children ≤12 years had significantly higher EV-A71 seropositivity rates than urban Kuala Lumpur children (95.5% vs 57.6%, P < 0.001), and also higher rates in the age groups of 1-3, 4-6 and 7-12 years. Multivariate analysis confirmed that age ≤12 years (adjusted OR 8.1, 95% CI 3.2-20.7, P < 0.001) and using untreated water (adjusted OR 6.2, 95% CI 2.3-16.6, P < 0.001) were independently associated with EV-A71 seropositivity in the Orang Asli population. Supply of clean drinking water may reduce the risk of EV-A71 infection. With significantly higher EV-A71 seropositive rates, younger rural children should be a priority target for future vaccination programs in Malaysia.
Erdemgil Y, Gözet T, Can Ö, Ünsal İ, Özpınar A. Perchlorate levels found in tap water collected from several cities in Turkey. Environmental Monitoring and Assessment. 2016 Mar;188(3):158. doi: 10.1007/s10661-016-5161-2.
Perchlorate is an inorganic anion that inhibits iodide transport to the thyroid by sodium-iodide transporters. Because perchlorate is highly soluble, stable, and mobile in water, drinking water is a potential source of perchlorate exposure. When exposed to perchlorate, thyroid dysfunction can be observed in sensitive populations (pregnant woman, infants, and children), especially those with iodide deficiency. The aim of this study was to determine the perchlorate levels in tap water from five cities in Turkey. Perchlorate concentrations of 145 tap water samples collected from Ankara, Isparta, Istanbul, Kayseri, and Sakarya were determined by liquid chromatography-tandem mass spectrometry. Mean and median values were found to be 0.15 and 0.07 μg/L, respectively. The median values (25-75 % percentile) of Istanbul, Ankara, Sakarya, Isparta, and Kayseri were 0.08 μg/L (0.04-0.09 μg/L), 0.07 μg/L (0.07-0.21 μg/L), 0.04 μg/L (0.04-0.04 μg/L), 0.03 μg/L (0.02-0.07 μg/L), and 0.25 μg/L (0.23-0.31 μg/L), respectively. The median perchlorate level observed in Kayseri was significantly higher than those found at other cities (p < 0.05). Perchlorate concentrations in water samples were lower than the interim drinking water health advisory level (15 μg/L) determined by the US Environmental Protection Agency. This study showed that perchlorate in drinking water is not the main source of exposure in these cities. Future studies should be performed to determine perchlorate levels in other potential sources, such as food products.