Daily Archives: April 9, 2016

Cruz California

“Sen. Ted Cruz (R-TX) wrapped up the remaining 13 Colorado delegates on Saturday at the state Republican Party convention, winning every pledged Republican delegate from Colorado to the Republican National Convention.” story here

Select Committee on Benghazi Stonewalled, Democrats Apathetic

Select Committee on Benghazi Chairman Trey Gowdy (SC-04) released the following statement after the committee today received from the State Department a production of more than 1,100 pages of records, including files stored on network folders used by senior employees within the Office of the Secretary, and emails from Cheryl Mills, Jake Sullivan, Huma Abedin, Susan Rice, and Patrick Kennedy:

“It is deplorable that it took over a year for these records to be produced to our committee, and that our Democrat colleagues never lifted a finger to help us get them. Shame on them and everyone else who has demanded this committee to give up before gathering all of the facts. This investigation is about a terrorist attack that killed four Americans, and it could have been completed a lot sooner if the administration had not delayed and delayed and delayed at every turn. For example, the committee still does not have records we requested over a year ago, and we are still waiting for some witnesses to be made available for interviews. As soon as possible, we will release our report and interview transcripts so everyone can see the evidence for themselves, and I’m confident the value and fairness of our investigation will then be abundantly clear to everyone.” click here

Fluoride Exposure and Testicular Toxicity

Wei R, Luo G, Sun Z, Wang S, Wang J. Chronic fluoride exposure-induced testicular toxicity is associated with inflammatory response in mice. Chemosphere. 2016 Mar 28;153:419-425. doi: 10.1016/j.chemosphere.2016.03.045.

Previous studies have indicated that fluoride (F) can affect testicular toxicity in humans and rodents. However, the mechanism underlying F-induced testicular toxicity is not well understood. This study was conducted to evaluate the sperm quality, testicular histomorphology and inflammatory response in mice followed F exposure. Healthy male mice were randomly divided into four groups with sodium fluoride (NaF) at 0, 25, 50, 100 mg/L in the drinking water for 180 days. At the end of the exposure, significantly increased percentage of spermatozoa abnormality was found in mice exposed to 50 and 100 mg/L NaF. Disorganized spermatogenic cells, vacuoles in seminiferous tubules and loss and shedding of sperm cells were also observed in the NaF treated group. In addition, chronic F exposure increased testicular interleukin-17(IL-17), interleukin-17 receptor C (IL-17RC), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in transcriptional levels, as well as IL-17 and TNF-α levels in translational levels. Interestingly, we observed that F treated group elevated testicular inducible nitric oxide synthase (iNOS) mRNA level and nitric oxide (NO) concentration. Taken together, these results indicated that testicular inflammatory response could contribute to chronic F exposure induced testicular toxicity in mice.