The linear-no threshold single-hit model is no longer valid as a default assumption for risk assessment

Edward J. Calabrese. The linear No-Threshold (LNT) dose response model: A comprehensive assessment of its historical and scientific foundations. Chemico-Biological Interactions. 301 (2019) 6–25. https://doi.org/10.1016/j.cbi.2018.11.020

The linear no-threshold (LNT) single-hit (SH) dose response model for cancer risk assessment is comprehensively assessed with respect to its historical foundations. This paper also examines how mistakes, ideological biases, and scientific misconduct by key scientists affected the acceptance, validity, and applications of the LNT model for cancer risk assessment. In addition, the analysis demonstrates that the LNT single-hit model was inappropriately adopted for governmental risk assessment, regulatory policy, practices, and for risk communication.

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