Daily Archives: March 26, 2020

Hydroxychloroquine found effective for treating COVID-19, France

Philippe Gautret, Jean-Christophe Lagierac, Philippe Parola et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents. https://doi.org/10.1016/j.ijantimicag.2020.105949

Background
Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the role of hydroxychloroquine on respiratory viral loads.

Patients and methods
French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point.

Results
Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms.

Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported of untreated patients in the literature. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.

Conclusion
Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.

What is the general population mortality rate of COVID-19? (Infection rate does not equal mortality rate.)

It is impossible to calculate a reliable rate of infection in the general population. For any infectious disease, there will be members of the population (e.g, Typhoid Mary) who will be asymptomatic (infected but show no symptoms). Some people will be infected but not seriously ill so they will not be tested or counted. Even some who are tested positive may not be because of false positive test results.

But data talks….You can count fatalities. So what is the general population mortality rate of COVID-19?

“Italy has had 3,400 COVID-19 deaths. They average nearly 23,000 flu deaths per year.” click here