Category Archives: Science

“Science denial” is a logical fallacy, an abusive ad hominum argument

Arguments that Japan is somehow “denying science” by affirming a commitment to fossil fuels (e.g. here) are simply false. It’s that simple. The “you are a science denier” argument is like the big bully throwing acid in another kids eyes. But it simply means the writer has no science-based arguments to support what he wants.

Hydroxychloroquine found effective for treating COVID-19, France

Philippe Gautret, Jean-Christophe Lagierac, Philippe Parola et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents. https://doi.org/10.1016/j.ijantimicag.2020.105949

Background
Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the role of hydroxychloroquine on respiratory viral loads.

Patients and methods
French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point.

Results
Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms.

Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported of untreated patients in the literature. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.

Conclusion
Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.

Yes it is easy to be fooled by a climate alarmist

“An article highly critical of my book Inconvenient Facts, a bestseller, has received wide distribution. It’s Easy to be Tricked by a Climate Denier purports to be a factual take-down of the book and, by extension, of me. However, it is really just one more example of how proponents of catastrophic man-made warming need to resort to lies and distortion in order to advance their agenda.” click here

“Well researched, clearly written, beautifully presented and, above all, fact-packed books such as Inconvenient Facts are absolutely essential to the very survival of democracy, to the restoration of true science, and to the ultimate triumph of objective truth. –Christopher Monckton, Viscount of Brenchley” 

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USEPA issues supplemental notice of regulatory science transparency rule

“This supplemental notice of proposed rulemaking (SNPRM) includes clarifications, modifications and additions to certain provisions published on April 30, 2018. This SNPRM proposes that the scope of the rulemaking apply to influential scientific information as well as significant regulatory decisions. This notice proposes definitions and clarifies that the proposed rulemaking applies to data and models underlying both pivotal science and pivotal regulatory science. In this SNPRM, EPA is also proposing a modified approach to the public availability provisions for data and models that would underly significant regulatory decisions and an alternate approach. Finally, EPA is taking comment on whether to use its housekeeping authority independently or in conjunction with appropriate environmental statutory provisions as authority for taking this action.” click here

Polar bears are doing just fine…withholding bear health and survival data does not change reality

Crockford, S.J. 2020. State of the Polar Bear Report 2019. Global Warming Policy Foundation Report 39, London.

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Falsified research is real

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No raw data, no publication

Tsuyoshi Miyakawa. No raw data, no science: another possible source of the reproducibility crisis. Molecular Brain  https://doi.org/10.1186/s13041-020-0552-2

A reproducibility crisis is a situation where many scientific studies cannot be reproduced. Inappropriate practices of science, such as HARKing, p-hacking, and selective reporting of positive results, have been suggested as causes of irreproducibility. In this editorial, I propose that a lack of raw data or data fabrication is another possible cause of irreproducibility.

As an Editor-in-Chief of Molecular Brain, I have handled 180 manuscripts since early 2017 and have made 41 editorial decisions categorized as “Revise before review,” requesting that the authors provide raw data. Surprisingly, among those 41 manuscripts, 21 were withdrawn without providing raw data, indicating that requiring raw data drove away more than half of the manuscripts. I rejected 19 out of the remaining 20 manuscripts because of insufficient raw data. Thus, more than 97% of the 41 manuscripts did not present the raw data supporting their results when requested by an editor, suggesting a possibility that the raw data did not exist from the beginning, at least in some portions of these cases.

Considering that any scientific study should be based on raw data, and that data storage space should no longer be a challenge, journals, in principle, should try to have their authors publicize raw data in a public database or journal site upon the publication of the paper to increase reproducibility of the published results and to increase public trust in science.